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Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi.

Abstract
Aim: To evaluate the antidiabetic properties of the aqueous extracts of C. molle twigs in rats. Methods: For the anti-hyperglycemic tests, the extracts at doses of 125, 250 and 500 mg/kg were administered orally to the normal rats and their glycemia was evaluated each 30 minutes during 4 hours. Type 1 diabetes was induced by the intra-peritoneal injection of alloxane (150 mg/kg) in rats. Type 2 diabetes was induced by the sub-cutaneous injection of the dexamethasone (1 mg/kg). Afterwards, animals were treated at doses 250 and 500 mg/kg of the decoction for 14 days (type 1 diabetes) and 8 days (type 2 diabetes). Body weight, glycemia, lipid parameters and atherogenic index were evaluated. Results: The decoction (250 mg/kg) produced a significant (p < 0.05) decrease in the postprandial glycemia at 90 minutes. However, at 120 minutes, a significant regulation of the blood glucose was observed at the dose of 500 mg/kg of the decoction (p < 0.01), maceration (p < 0.05) and infusion (p < 0.05). In addition, the doses 250 and 500 mg/kg of the decoction of C. molle prevented a significant reduction in body weight, hyperglycemia and dyslipidemia, and a significant increase in atherogenic index, which were observed in the type 1 and 2 diabetic subjects. Conclusion: The decoction was showed the greatest hypoglycemic and anti-hyperglycemic activities, thereby confirming his ethnopharmacological use of this extract in the management of diabetes mellitus.

Key words: Combretum molle, diabetes mellitus, lipid profile, aqueous extracts, Wistar rats


 
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Pubmed Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Prog Med Sci. 2017; 1(1): 1-8. doi:10.5455/pms.286448


Web Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. http://www.promedsci.org/?mno=286448 [Access: November 19, 2018]. doi:10.5455/pms.286448


AMA (American Medical Association) Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Prog Med Sci. 2017; 1(1): 1-8. doi:10.5455/pms.286448



Vancouver/ICMJE Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Prog Med Sci. (2017), [cited November 19, 2018]; 1(1): 1-8. doi:10.5455/pms.286448



Harvard Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi (2017) Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Prog Med Sci, 1 (1), 1-8. doi:10.5455/pms.286448



Turabian Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. 2017. Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Progress in Medical Sciences, 1 (1), 1-8. doi:10.5455/pms.286448



Chicago Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. "Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats." Progress in Medical Sciences 1 (2017), 1-8. doi:10.5455/pms.286448



MLA (The Modern Language Association) Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi. "Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats." Progress in Medical Sciences 1.1 (2017), 1-8. Print. doi:10.5455/pms.286448



APA (American Psychological Association) Style

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi (2017) Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats. Progress in Medical Sciences, 1 (1), 1-8. doi:10.5455/pms.286448





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