E-ISSN 2577-2996


Progress in Medical Sciences. 2018; 2(1):(17-52)


A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats

Kingsley Afoke Iteire, Victor Emojevwe

Abstract
Background: Phoenix dactilifera (PD) has been used as a medicinal remedy for swollen limbs, aching legs, cough, sneezing, and acceleration of hair growth. Although studies have suggested the beneficial aspects of this agent to human health, it is not yet clear of the dosage that may become detrimental. Methods: Twenty adult albino rats divided into four groups of five rats each were used in this experiment. Methanol extract of PD was orally administered at doses of 4, 8, and 16 mg/kg to groups 2, 3, and 4, respectively, while group 1 (control) received distilled water. After 8 hours, blood was collected from the animals for the assessment of packed cell volume, serum urea, creatinine, glucose, potassium, chloride, and sodium. The data generated were expressed as the mean ± standard error of mean. The means were compared with Student’s t-test and analysis of variance with a p-value of 0.05 considered statistically significant. Results: In all parameters analyzed, kidney function was improved only at doses of 4 and 8 mg/kg, which was attributed to the antioxidant and free radical scavenging properties of PD. A higher dose of 16 mg/kg significantly increased the K+ (36.0 ± 4.5/22.6 ± 2.3 mEq/l) and serum urea (32.0 ± 3.8 mg/dl/25.2 ± 1.4 mg/dl) concentrations when compared with the control but other parameters measured were unchanged. These revealed that high doses of PD might impair normal renal functions. Conclusions: It was, therefore, concluded that methanol extract of PD fruit improved kidney functions at doses of 4 and 8 mg/kg and that at 16 mg/kg, PD might be deleterious to the kidney by impairing urea and potassium excretion
Most Viewed Article
  • Clinical Diagnosis and Treatment of Absence Seizures: Case Study
    Asif Bilal
    » Abstract » doi: 10.5455/pms.20211021

  • Telephone Consultations by Medical Scheme Patients for Covid-19 Related Diagnosis-2020, South Africa
    Michael Mncedisi Willie
    » Abstract » doi: 10.5455/pms.20211020

  • Impact of the Covid-19 Pandemic on Oncology Consultations and Practical Management Recommendations
    Oumayma Bounid*, Mariem Elanigri, Youness El-Khadir, Mouna Darfaoui, Issam Lalya, Abdelhamid El Omrani, Mouna Khouchani
    » Abstract » doi: 10.5455/pms.20211019

  • A Study of Vitamin D Status in Type 2 Diabetes Mellitus and Association of Vitamin D Levels with Glycemic Control
    Fahmida Khatoon1*, Shimaa Mohammed Hasnin Aboelnaga2, Abdulsalam Al- Mhwes3, Bashir Ahmed4 and Zahid Balouch5
    » Abstract » doi: 10.5455/pms.20211018

  • Invasive Ductal Carcinoma of the Breast Presenting as Hypercalcemic Encephalopathy
    Zohra R. Malik1 and Zareen Razaq2
    » Abstract » doi: 10.5455/pms.20211CE108

Most Downloaded
  • Clinical Diagnosis and Treatment of Absence Seizures: Case Study
    Asif Bilal
    » Abstract » doi: 10.5455/pms.20211021

  • Telephone Consultations by Medical Scheme Patients for Covid-19 Related Diagnosis-2020, South Africa
    Michael Mncedisi Willie
    » Abstract » doi: 10.5455/pms.20211020

  • Impact of the Covid-19 Pandemic on Oncology Consultations and Practical Management Recommendations
    Oumayma Bounid*, Mariem Elanigri, Youness El-Khadir, Mouna Darfaoui, Issam Lalya, Abdelhamid El Omrani, Mouna Khouchani
    » Abstract » doi: 10.5455/pms.20211019

  • A Study of Vitamin D Status in Type 2 Diabetes Mellitus and Association of Vitamin D Levels with Glycemic Control
    Fahmida Khatoon1*, Shimaa Mohammed Hasnin Aboelnaga2, Abdulsalam Al- Mhwes3, Bashir Ahmed4 and Zahid Balouch5
    » Abstract » doi: 10.5455/pms.20211018

  • Invasive Ductal Carcinoma of the Breast Presenting as Hypercalcemic Encephalopathy
    Zohra R. Malik1 and Zareen Razaq2
    » Abstract » doi: 10.5455/pms.20211CE108