E-ISSN 2577-2996


Progress in Medical Sciences. 2019; 3(1):(18-19)


Effect of Trema guineensis (Celtidaceae) on ethanol-induced hypertension in Wistar rats

Balakiyém Kadissoli, Piwèlong Aklesso Mouzou, Tcha Pakoussi, Kwashi Eklu-Gadegbeku, Amedonou Kodjo Aklikokou, Messanvi Gbeassor

Abstract
Objective: Trema guineensis is a traditional medicinal plant used to treat cardiovascular diseases in Africa. Here, we evaluated the effects of its hydro-alcoholic leaves on ethanol-induced hypertension. Method: Four groups of five rats each were used in this study. Group I, the control group, received distilled water (10 ml kg-1), Group II received ethanol (35°) at 3 g/kg, and Groups III and IV received ethanol (35°) at 3 g/kg followed by 200 and 400 mg/kg extract, respectively. Ethanol solutions were administered over 8 weeks. Results: The ethanol solutions increased body weight, blood pressure, superoxide dismutase (SOD), and malondialdehyde (MDA), and reduced glutathione (GSH) and nitric oxide (NO). As for the hematological parameters, the ethanol solutions reduced hemoglobin, red blood cells, white blood cells, platelets, polymorphonuclear cells, and lymphocytes, as well as corpuscular volume compared with the control group. The T. guineensis extract significantly prevented increased body weight, blood pressure, SOD, MDA, GSH, and NO. The extract also normalized hematological parameters. Conclusion: These results suggest that this extract contains antihypertensive properties that protect against ethanol-induced hypertension
Most Viewed Article
  • A review on unconventional methods for the diagnosis of drowning
    Ritwik Ghosh, Saikat Das, Soumeek Chowdhuri
    » Abstract » doi: 10.5455/pms.20191007023932

  • Effect of Trema guineensis (Celtidaceae) on ethanol-induced hypertension in Wistar rats
    Balakiyém Kadissoli, Piwèlong Aklesso Mouzou, Tcha Pakoussi, Kwashi Eklu-Gadegbeku, Amedonou Kodjo Aklikokou, Messanvi Gbeassor
    » Abstract » doi: 10.5455/pms.20181117061747

  • A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats
    Kingsley Afoke Iteire, Victor Emojevwe
    » Abstract » doi: 10.5455/pms.20181023124229

  • Experience of interpersonal violence and subjective levels of aggression among healthcare staff in a Nigerian hospital
    Lateef Olutoyin Oluwole, Adetunji Obadeji, Mobolaji Usman Dada
    » Abstract » doi: 10.5455/pms.20190428010612

  • Extreme resistance of Enterococcus faecalis and its role in endodontic treatment failure
    Ashwini Savia Colaco
    » Abstract » doi: 10.5455/pms.20180116070109

Most Downloaded
  • A review on unconventional methods for the diagnosis of drowning
    Ritwik Ghosh, Saikat Das, Soumeek Chowdhuri
    » Abstract » doi: 10.5455/pms.20191007023932

  • Effect of Trema guineensis (Celtidaceae) on ethanol-induced hypertension in Wistar rats
    Balakiyém Kadissoli, Piwèlong Aklesso Mouzou, Tcha Pakoussi, Kwashi Eklu-Gadegbeku, Amedonou Kodjo Aklikokou, Messanvi Gbeassor
    » Abstract » doi: 10.5455/pms.20181117061747

  • A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats
    Kingsley Afoke Iteire, Victor Emojevwe
    » Abstract » doi: 10.5455/pms.20181023124229

  • Experience of interpersonal violence and subjective levels of aggression among healthcare staff in a Nigerian hospital
    Lateef Olutoyin Oluwole, Adetunji Obadeji, Mobolaji Usman Dada
    » Abstract » doi: 10.5455/pms.20190428010612

  • Extreme resistance of Enterococcus faecalis and its role in endodontic treatment failure
    Ashwini Savia Colaco
    » Abstract » doi: 10.5455/pms.20180116070109