Objective: To explore the protein composition of commonly consumed freshwater fish species and their potential role in accelerating healing in chronic diseases and burn injuries. 

Methods: This literature-based review compiles existing biochemical data on high-protein freshwater fish such as Clarias batrachus (catfish), Oreochromis niloticus (tilapia), and Pangasius hypophthalmus (pangasius), with emphasis on their protein structure, essential amino acid content, and therapeutic implications in healing processes.

Results: Freshwater fish species contain 18–24% high-quality protein. Key amino acids such as arginine, glutamine, glycine, and leucine are abundant, supporting collagen synthesis, immune responses, and tissue regeneration. These proteins have been shown to promote angiogenesis, fibroblast activity, and epithelialization in infected wounds and burn injuries. 

Conclusion: Regular intake of freshwater fish with high protein content provides essential nutrients that significantly enhance wound healing and infection recovery. Their integration into clinical nutritional support should be encouraged for patients with chronic wounds or burn injuries.