Major contributors for office workers to acquire musculoskeletal disorders are prolonged sitting, poor postures, and repetition of tasks in a sedentary work environment. Reduced productivity, higher absenteeism and long term health complications are things they cause. Physical therapy (PT) is done to prevent and address MSDs in the main ways of ergonomic positioning, exercise interventions and workplace wellness programs. MSDs develop at a slower pace when posture is corrected, and then stretch-out routines along with strengthening of weak muscle groups are focused through PT for employees. If, however, you're finding it hard to maintain good posture, ergonomics assessment and modifications to your working setup (chair, desk, monitor elevation, etc.) will definitely assist your spine aligning and relieve strain on your muscle and skeletal system. Innovative interventions, such as virtual, ergonomics-based assessment tools to extend the efficacy of PT, further include wearable posture correction devices. This paper researches the impact of physical therapy on ergonomic positioning and workplace wellness to find evidence-based methods of encouraging employee health. The relevance of using PT in organizational wellness programs is relevant for the two purposes of preventing MSDs and increasing productivity, as shown by analyzing recent studies and practical applications in this paper. The findings suggest that ergonomic education in conjunction with regular physical activity and PT customized intervention create a healthy and sustainable working environment.