Methods: Twelve (12) male weaning Wistar rats (40-60g) were randomly divided into four groups (n=3). Group A and B were placed on a normal salt diet while Group C and D were placed on a high salt diet for ten (10) weeks. Carotid artery was then isolated, canulated and connected to a SP844 physiological pressure transducer attached to a PowerLab 8SP unit for blood pressure measurement. AO bark extract (0.1mg/ml) was then administered intravenously in different concentrations (0.01, 0.1, 1.0, and 10, 100 μg/ml) through the jugular vein in 0.1ml/dose to Group A and C while Nifedipine was administered in different concentrations (0.04, 0.4, 4.0, and 40, 200 μg/ml) to groups B and D. The data were analyzed using unpaired-student t test and non-linear regression curve were generated using Graphpad-prism version 8 at 95% confidence interval 
Results: SBP, DBP, HR and MAP (141.06±4.27, 109.99±4.26, 398±13.25, 120.35±4.25 were significantly higher in HS animals than the NS animals (103.69±11.56, 79.34±4.07, 354±66.96, 77.07±8.17) respectively. Nifedipine was able to reduce DBP and MAP were reduced in a dose dependent faction while AO bark extract reduced all blood pressure parameters in dose dependent faction in HS and NS animals 
Conclusion: We therefore concluded that Anacardium occidentale bark extract was able to reduce blood pressure parameters in a dose-dependent manner than nifedipine in this study