One of the most advanced developments in medical ablation technology is High-Intensity Ultrasound (HIU). This technology offers precise and minimally invasive treatment for several ailments, such as breast cancer, prostate cancer, and renal denervation (RDN). Technology uses ultrasound transducers to emit targeted pressure waves that generate heat within tissues, resulting in localized ablation while sparing surrounding areas. This paper explores the principles, applications, and advancements in ultrasound ablation, including intravascular non-focused Ultrasound for RDN and the evolving role of HIU in oncological and non-oncological treatments. In this paper, ultrasound ablation technology, HIU system designs, transducer materials, and bench evaluations are addressed, and the effects and range, as well as the future of ultrasound ablation technologies are explored in the field of medical devices and biomedical applications.